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Abstract To facilitate the study of solar flares and active regions, we have created a modeling framework, the freely distributed GX Simulator IDL package, that combines 3D magnetic and plasma structures with thermal and nonthermal models of the chromosphere, transition region, and corona. Its object-based modular architecture, which runs on Windows, Mac, and Unix/Linux platforms, offers the ability to either import 3D density and temperature distribution models, or to assign numerically defined coronal or chromospheric temperatures and densities, or their distributions, to each individual voxel. GX Simulator can apply parametric heating models involving average properties of the magnetic field lines crossing a given voxel, as well as compute and investigate the spatial and spectral properties of radio, (sub)millimeter, EUV, and X-ray emissions calculated from the model, and quantitatively compare them with observations. The package includes a fully automatic model production pipeline that, based on minimal users input, downloads the required SDO/HMI vector magnetic field data, performs potential or nonlinear force-free field extrapolations, populates the magnetic field skeleton with parameterized heated plasma coronal models that assume either steady-state or impulsive plasma heating, and generates non-LTE density and temperature distribution models of the chromosphere that are constrained by photospheric measurements. The standardized models produced by this pipeline may be further customized through specialized IDL scripts, or a set of interactive tools provided by the graphical user interface. Here, we describe the GX Simulator framework and its applications.